Description:
Regression model of sensillum SBT-II-A with 10 QuBiLS-MIDAS descriptors used for prediction of spike amplitude of the extracellularly record of ORN response potentials of the antennal trichoid sensilla to Cx.
quinquefasciatus repellents.
The training was performed with Vote algorithm as default in Weka 3.9.4 with a 10-fold cross-validation using a combination of the average of probabilities (agglomeration rule) of Gaussian Processes (with Pearson
Universal Kernel (PUK)), Linear Regression, and IBk (with K-nearest neighbors (KNN) = 10 and True cross-validation). The 10 QuBiLS-MIDAS descriptors are namely:
MX_TrB_AB_nCi_3_M19(M1)_SS7_T_LG3P[1]_LGP[1]_r-p_MID
AC[4]_S_F_AB_nCi_2_M11_SS2_T_LGP[2]_c_MID
SD_TrB_AB_nCi_3_M19(M11)_MP4_T_LGTP[12-13]_r-p_MID
GV[1]_K_Tr_AB_nCi_3_M25(M15)_NS1_T_KA_m-a-c_MID
VC_TrQB_AB_nCi_3_M26(M10)_SS7_T_LGBA[0.0-0.314]_m-r_MID
AC[3]_K_Tr_AB_nCi_3_M21(M8)_SS1_T_KA_m-a-c_MID
S_Tr_AB_nCi_3_M25(M13)_NS7_T_LGA[1.0-2.0]_a-e-v_MID
S_Tr_AB_nCi_3_M25(M2)_NS6_T_KA_a-e-v_MID
TS[1]_K_TrC_AB_nCi_3_M27_SS1_T_KA_p_MID
AC[5]_I50_TrB_AB_nCi_3_M20(M16)_SS2_T_KA_e-v_MID
Training set:
50 compounds extracted from the Liu, et al., 2013 original experimental research constitute the training set 10.1016/j.jinsphys.2013.08.016
Performance:
For a 10-fold cross-validation, the statistical parameters (performance without applicability domain) are R = 0.8569, MAE = 5.9322, RMSE = 7.7384, RAE = 67.988 %, and RRSE = 59.4346 %.
Classification Breakpoint:
The breakpoint for sensillum SBT-II-A is 20.4 spikes/s. Values greater than or equal to the breakpoint will elicit a response in this specific sensillum. Lower values represent certain actions occurring, however,
they are not enough to activate the sensillum response.
Reference:
Liu et al. Olfactory responses of the antennal trichoid sensilla to chemical repellents in the mosquito, Culex quinquefasciatus. 2013, 59(11), 1169-1177.
DOI: 10.1016/j.jinsphys.2013.08.016