Description:
Classification model developed to predict the spike amplitude of the extracellularly record of ORN response potentials of the antennal trichoid sensilla to Cx. quinquefasciatus in two classes: POSITIVE or NEGATIVE.
The breakpoint for sensillum SST-C is 13.5 spikes/s. Values greater than or equal to the breakpoint will elicit a response in this specific sensillum and are represented as POSITIVE. Lower values represent certain
actions occurring, however, these are not enough to activate the sensillum response, these are classified as NEGATIVE.
The training was performed with Logistic algorithm as default in Weka 3.9.4 with a 10-fold cross-validation. A number of 4 QuBiLS-MIDAS descriptors are in the classification model, namely:
TS[1]_I50_TrC_AB_nCi_3_M27_SS2_T_KA_v_MID
RA_Tr_AB_nCi_3_M19(M15)_MP7_T_KA_a-e-v_MID
N1_TrF_AB_nCi_3_M20(M16)_MP1_T_LGBA[1.570-1.884]_h_MID
VC_TrC_AB_nCi_3_M22(M3)_SS2_T_LG3L[2-3]_LGL[2-3]_h_MID
Training set:
50 compounds extracted from the Liu, et al., 2013 original experimental research constitute the training set 10.1016/j.jinsphys.2013.08.016
Performance:
For a 10-fold cross-validation, the statistical parameters (Performance without applicability domain) are MCC = 0.869, ROC Area = 0.872, PRC Area = 0.863, TP Rate = 0.94, FP Rate = 0.116, Q (%) = 94, and Precision
= 0.945.
Reference:
Liu et al. Olfactory responses of the antennal trichoid sensilla to chemical repellents in the mosquito, Culex quinquefasciatus. 2013, 59(11), 1169-1177.
DOI: 10.1016/j.jinsphys.2013.08.016