Description:
Classification model developed to predict the spike amplitude of the extracellularly record of ORN response potentials of the antennal trichoid sensilla to Cx. quinquefasciatus in two classes: POSITIVE or NEGATIVE.
The breakpoint for sensillum SBT-II-B is 32.8 spikes/s. Values greater than or equal to the breakpoint will elicit a response in this specific sensillum and are represented as POSITIVE. Lower values represent
certain actions occurring, however, these are not enough to activate the sensillum response, these are classified as NEGATIVE.
The training was performed with IBk (with K-nearest neighbors (KNN) = 10 and True cross-validation) algorithm in Weka 3.9.4 with a 10-fold cross-validation. A number of 5 QuBiLS-MIDAS descriptors are in the
classification model, namely:
ES_S_F_AB_nCi_2_M12_MP7_n_T_LGP[5]_a_MID
Q3_B_AB_nCi_2_M10_MP4_o_T_LGL[2-3]_e-s_MID
S_B_AB_nCi_2_M3_SS4_T_LGL[2-3]_p-h_MID
Q3_B_AB_nCi_2_M11_MP3_o_T_LGL[2-3]_v-s_MID
AC[2]_K_F_AB_nCi_2_M8_SS5_T_LGP[1]_a_MID
Training set:
50 compounds extracted from the Liu, et al., 2013 original experimental research constitute the training set 10.1016/j.jinsphys.2013.08.016
Performance:
For a 10-fold cross-validation, the statistical parameters (Performance without applicability domain) are MCC = 0.941, ROC Area = 0.913, PRC Area = 0.951, TP Rate = 0.98, FP Rate = 0.071, Q (%) = 98, and Precision
= 0.98.
Reference:
Liu et al. Olfactory responses of the antennal trichoid sensilla to chemical repellents in the mosquito, Culex quinquefasciatus. 2013, 59(11), 1169-1177.
DOI: 10.1016/j.jinsphys.2013.08.016