Description:
Classification model developed to predict the spike amplitude of the extracellularly record of ORN response potentials of the antennal trichoid sensilla to Cx. quinquefasciatus in two classes: POSITIVE or NEGATIVE. The breakpoint for sensillum SBT-I-B is 16.3 spikes/s. Values greater than or equal to the breakpoint will elicit a response in this specific sensillum and are represented as POSITIVE. Lower values represent certain actions occurring, however, these are not enough to activate the sensillum response, these are classified as NEGATIVE.

The training was performed with Bagging algorithm as default in Weka 3.9.4 with a 10-fold cross-validation using Random Forest as classifier. A number of 7 QuBiLS-MIDAS descriptors are in the classification model, namely:

AC[1]_S_B_AB_nCi_2_M8_NS1_o_T_LGP[2]_m-h_MID
S_F_AB_nCi_2_M14_NS2_n_T_LGL[2-3]_c_MID
MX_Q_AB_nCi_2_M8_SS3_T_LGP[2]_v_MID
GV[5]_N2_TrC_AB_nCi_3_M19(M16)_MP2_T_KA_v_MID
Q3_Q_AB_nCi_2_M11_MP7_T_LGL[1-2]_s_MID
HM_Q_AB_nCi_2_M12_SS4_T_LGP[5]_p_MID
ES_SD_F_AB_nCi_2_M1_SS1_T_LGP[5]_a_MID

Training set:
50 compounds extracted from the Liu, et al., 2013 original experimental research constitute the training set 10.1016/j.jinsphys.2013.08.016

Performance:
For a 10-fold cross-validation, the statistical parameters (Performance without applicability domain) are MCC = 0.557, ROC Area = 0.804, PRC Area = 0.799, TP Rate = 0.776, FP Rate = 0.226, Q (%) = 77.6119, and Precision = 0.782.

Reference:
Liu et al. Olfactory responses of the antennal trichoid sensilla to chemical repellents in the mosquito, Culex quinquefasciatus. 2013, 59(11), 1169-1177. DOI: 10.1016/j.jinsphys.2013.08.016