Description:
Regression ensemble of sensillum SBT-II-A with 2 individual models (I14 and I21) used for prediction of spike amplitude of the extracellularly record of ORN response potentials of the antennal trichoid sensilla
to Cx. quinquefasciatus repellents.
The training was performed with the Linear Regression algorithm as default in Weka 3.9.4 with a 10-fold cross-validation. Models I14 and I21 were developed by using in both cases, 6 QuBiLS-MIDAS descriptors,
respectively, namely:
AC[5]_I50_F_AB_nCi_2_M1_SS0_T_LGL[2-3]_v_MID
Q2_B_AB_nCi_2_M3_NS3_T_LGL[1-2]_r-h_MID
AC[1]_S_F_AB_nCi_2_M1_SS7_o_T_LGL[5-6]_c_MID
AC[4]_K_F_AB_nCi_2_M14_MP1_n_T_LGP[5]_h_MID
AC[4]_S_F_AB_nCi_2_M12_MP7_n_T_LGP[5]_c_MID
MN_Q_AB_nCi_2_M14_NS1_T_LGL[1-2]_h_MID
AC[1]_S_F_AB_nCi_2_M15_SS1_T_LGP[2]_c_MID
K_B_AB_nCi_2_M13_NS1_o_T_LGL[1-2]_h-s_MID
AC[5]_I50_TrB_AB_nCi_3_M20(M16)_SS2_T_KA_e-v_MID
Q3_B_AB_nCi_2_M5_NS6_T_LGL[1-2]_p-h_MID
AC[5]_S_Q_AB_nCi_2_M12_MP0_T_LGL[1-2]_h_MID
Training set:
50 compounds extracted from the Liu, et al., 2013 original experimental research constitute the training set 10.1016/j.jinsphys.2013.08.016
Performance:
For a 10-fold cross-validation, the statistical parameters (performance without applicability domain) are R = 0.9601, MAE = 1.821, RMSE = 3.58, RAE = 20.8705 %, and RRSE = 27.4958 %.
Classification Breakpoint:
The breakpoint for sensillum SBT-II-A is 20.4 spikes/s. Values greater than or equal to the breakpoint will elicit a response in this specific sensillum. Lower values represent certain actions occurring, however,
they are not enough to activate the sensillum response.
Reference:
Liu et al. Olfactory responses of the antennal trichoid sensilla to chemical repellents in the mosquito, Culex quinquefasciatus. 2013, 59(11), 1169-1177.
DOI: 10.1016/j.jinsphys.2013.08.016