Description:
Classification model developed to predict the spike amplitude of the extracellularly record of ORN response potentials of the antennal trichoid sensilla to Cx. quinquefasciatus in two classes: POSITIVE or NEGATIVE.
The breakpoint for sensillum SST is 43 spikes/s. Values greater than or equal to the breakpoint will elicit a response in this specific sensillum and are represented as POSITIVE. Lower values represent certain
actions occurring, however, these are not enough to activate the sensillum response, these are classified as NEGATIVE.
The training was performed with Stochastic Gradient Descent (SGD) algorithm as default in Weka 3.9.4 with a 10-fold cross-validation. A number of 10 QuBiLS-MIDAS descriptors are in the classification model, namely:
S_F_AB_nCi_2_M14_NS2_n_T_LGL[2-3]_v_MID
AC[4]_S_B_AB_nCi_2_M5_NS6_T_LGL[1-2]_m-s_MID
MN_Q_AB_nCi_2_M10_SS2_T_LGP[2]_v_MID
K_B_AB_nCi_2_M3_NS7_T_LGL[2-3]_r-v_MID
TS[2]_I50_F_AB_nCi_2_M15_MP1_T_KA_alk_MID
GV[3]_N2_TrC_AB_nCi_3_M19(M15)_MP3_T_KA_v_MID
ES_I50_F_AB_nCi_2_M1_SS0_T_LGL[2-3]_e_MID
N2_F_AB_nCi_2_M12_NS5_T_LGL[1-2]_a_MID
VC_TrC_AB_nCi_3_M20(M16)_SS3_T_LGTP[12-13]_p_MID
K_F_AB_nCi_2_M10_SS7_o_T_LGP[2]_a_MID
Training set:
50 compounds extracted from the Liu, et al., 2013 original experimental research constitute the training set 10.1016/j.jinsphys.2013.08.016
Performance:
For a 10-fold cross-validation, the statistical parameters (Performance without applicability domain) are MCC = 0.83, ROC Area = 0.905, PRC Area = 0.882, TP Rate = 0.92, FP Rate = 0.11, Q (%) = 92, and Precision
= 0.921.
Reference:
Liu et al. Olfactory responses of the antennal trichoid sensilla to chemical repellents in the mosquito, Culex quinquefasciatus. 2013, 59(11), 1169-1177.
DOI: 10.1016/j.jinsphys.2013.08.016