Description:
Classification model developed to predict the spike amplitude of the extracellularly record of ORN response potentials of the antennal trichoid sensilla to Cx. quinquefasciatus in two classes: POSITIVE or NEGATIVE. The breakpoint for sensillum SBT-II-B is 32.8 spikes/s. Values greater than or equal to the breakpoint will elicit a response in this specific sensillum and are represented as POSITIVE. Lower values represent certain actions occurring, however, these are not enough to activate the sensillum response, these are classified as NEGATIVE.

The training was performed with Bagging algorithm as default in Weka 3.9.4 with a 10-fold cross-validation using the Logistic function as classifier. A number of 8 QuBiLS-MIDAS descriptors are in the classification model, namely:

Q3_B_AB_nCi_2_M10_MP4_o_T_LGL[2-3]_e-s_MID
MN_B_AB_nCi_2_M14_SS2_T_LGP[2]_v-h_MID
AC[2]_K_B_AB_nCi_2_M3_NS0_n_T_LGP[2]_e-p_MID
Q3_B_AB_nCi_2_M11_MP3_o_T_LGL[2-3]_v-s_MID
AC[2]_K_F_AB_nCi_2_M8_SS5_T_LGP[1]_a_MID
N3_Q_AB_nCi_2_M4_MP5_o_T_LGST(PI)[0.0-1.0]_e_MID
GM_B_AB_nCi_2_M14_MP3_T_LGL[1-2]_v-s_MID
I50_B_AB_nCi_2_M10_SS1_T_LGP[1]_e-s_MID

Training set:
50 compounds extracted from the Liu, et al., 2013 original experimental research constitute the training set 10.1016/j.jinsphys.2013.08.016

Performance:
For a 10-fold cross-validation, the statistical parameters (Performance without applicability domain) are MCC = 1, ROC Area = 1, PRC Area = 1, TP Rate = 1, FP Rate = 0, Q (%) = 100, and Precision 1.

Reference:
Liu et al. Olfactory responses of the antennal trichoid sensilla to chemical repellents in the mosquito, Culex quinquefasciatus. 2013, 59(11), 1169-1177. DOI: 10.1016/j.jinsphys.2013.08.016