Description:
Classification model developed to predict the spike amplitude of the extracellularly record of ORN response potentials of the antennal trichoid sensilla to Cx. quinquefasciatus in two classes: POSITIVE or NEGATIVE.
The breakpoint for sensillum SST is 43 spikes/s. Values greater than or equal to the breakpoint will elicit a response in this specific sensillum and are represented as POSITIVE. Lower values represent certain
actions occurring, however, these are not enough to activate the sensillum response, these are classified as NEGATIVE.
The training was performed with Bagging algorithm as default in Weka 3.9.4 with a 10-fold cross-validation using Stochastic Gradient Descent function (SGD) as classifier. A number of 7 QuBiLS-MIDAS descriptors are
in the classification model, namely:
RA_TrF_AB_nCi_3_M21(M13)_MP6_T_LG3L[2-3]_LGL[2-3]_p_MID
ES_I50_Q_AB_nCi_2_M1_SS1_n_T_LGP[1]_e_MID
ES_S_B_AB_nCi_2_M3_SS6_T_LGP[2]_a-e_MID
AC[4]_S_B_AB_nCi_2_M5_NS6_T_LGL[1-2]_m-s_MID
MN_Q_AB_nCi_2_M10_SS2_T_LGP[2]_v_MID
ES_I50_F_AB_nCi_2_M1_SS0_T_LGL[2-3]_e_MID
N2_F_AB_nCi_2_M12_NS5_T_LGL[1-2]_a_MID
Training set:
50 compounds extracted from the Liu, et al., 2013 original experimental research constitute the training set 10.1016/j.jinsphys.2013.08.016
Performance:
For a 10-fold cross-validation, the statistical parameters (Performance without applicability domain) are MCC = 0.876, ROC Area = 0.945, PRC Area = 0.941, TP Rate = 0.94, FP Rate = 0.098, Q (%) = 94, and Precision
= 0.945.
Reference:
Liu et al. Olfactory responses of the antennal trichoid sensilla to chemical repellents in the mosquito, Culex quinquefasciatus. 2013, 59(11), 1169-1177.
DOI: 10.1016/j.jinsphys.2013.08.016