SiliS-PTOXRA, acronym of DRY-in Silico Screening & Prediction of Toxic Hazard and Risk Assessment, was developed for the prediction of toxicological endpoints. Three consensus models to predict Acute Oral Toxicity (AOT) are the first ones in being incorporated to this software. This program was implemented in Java 1.8; thus, it is fully cross-platform. For the development of the SiliS-PTOXRA software, the CDK (v1.4.19), QuBiLS-MAS, AMBIT (v0.0.4) and WEKA (v3.8.0) toolkits were used as libraries for the manipulation of the chemical structures, computation of the molecular descriptors, computation of the applicability domain (AD) and prediction of AOT using the models built, respectively.